NEUROTOXICANTS AND GAMMA-AMINOBUTYRIC ACID RECEPTORS
نویسندگان
چکیده
منابع مشابه
gamma-Aminobutyric acid and benzodiazepine receptors: copurification and characterization.
gamma-Aminobutyric acid (GABA) and benzodiazepine receptors have been solubilized and purified by procedures such as gel filtration, ion-exchange, lectin, and affinity chromatographies. All of these procedures enhance the specific activity of each receptor to a similar extent. The drug specificities of [3H]muscimol and [3H]flunitrazepam binding sites are the same after extensive purification by...
متن کاملEvolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors.
Gamma-aminobutyric acid (GABA) and glutamate are two important amino acid neurotransmitters widely present in the nervous systems of mammals, insects, round worm, and platyhelminths, while their receptors are quite diversified across different animal phyla. However, the evolutionary mechanisms between the two conserved neurotransmitters and their diversified receptors remain elusive, and antago...
متن کاملA Review on Gamma-aminobutyric Acid (gaba) and Its Receptors
The inhibitory neurotransmitter, γ-aminobutyric acid (GABA), activates a variety of receptors in all areas of the central nervous system (CNS). GABA acts at inhibitory synapses in the brain by binding to specific transmembrane receptors in the plasma membrane of both pre and postsynaptic neuronal processes. There are three classes of GABA receptors. GABAA and GABAC receptors are ionotropic in n...
متن کاملGamma aminobutyric acid and glycine receptors in the nucleus
Gamma aminobutyric acid and glycine receptors in the nucleus ambiguus mediate 1 tachycardia elicited by chemical stimulation of the hypothalamic arcuate nucleus 2 3 Vineet C. Chitravanshi, Kazumi Kawabe and Hreday N. Sapru 4 5 Department of Neurological Surgery, Rutgers New Jersey Medical School, 185 South Orange 6 Avenue, Newark, NJ 07103, USA 7 8 9 10 Short title: Arcuate nucleus: heart rate ...
متن کاملgamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus.
Most of the actions of neurosteroids on the central nervous system are mediated through allosteric modulation of the gamma-aminobutyric acid type A (GABA(A)) receptor, but a direct effect of GABA on the regulation of neurosteroid biosynthesis has never been investigated. In the present report, we have attempted to determine whether 3beta-hydroxysteroid dehydrogenase (3beta-HSD)-containing neuro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1990
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.15.supplementiv_3